Search results for "Long-living individual"

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Age-associated changes in circulatory fatty acids: new insights on adults and long-lived individuals

2022

Long-lived individuals (LLIs) are considered an ideal model to study healthy human aging. Blood fatty acid (FA) profile of a cohort of LLIs (90–111 years old, n = 49) from Sicily was compared to adults (18–64 years old, n = 69) and older adults (65–89 years old, n = 54) from the same area. Genetic variants in key enzymes related to FA biosynthesis and metabolism were also genotyped to investigate a potential genetic predisposition in determining the FA profile. Gas chromatography was employed to determine the FA profile, and genotyping was performed using high-resolution melt (HRM) analysis. Blood levels of total polyunsaturated FA (PUFA) and total trans-FA decreased with age, while the lev…

Settore MED/04 - Patologia GeneraleAgingGenotypingLong-living individualFatty acid desaturaseLipidomicLongevityFatty acid elongaseFatty acidLong-living individualsFatty acid desaturase; Fatty acid elongase; Fatty acids; Genotyping; Lipidomics; Long-living individuals; LongevityLipidomicsOriginal ArticleGeriatrics and GerontologyFatty acids

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